Everything about Noradrenaline Reuptake Inhibitor totally explained
Norepinephrine reuptake inhibitors (
NRIs), also known as
noradrenaline reuptake inhibitors (
NARIs), are compounds that elevate the extracellular level of the
neurotransmitter norepinephrine in the
central nervous system by inhibiting its
reuptake from the
synaptic cleft into the presynaptic neuronal terminal. The drugs inhibit the class of
neurotransmitter transporters known as
norepinephrine transporters. They have virtually no action at other
monoamine transporters.
List of NRIs
Strattera is available in the United States and is indicated by the
Food and Drug Administration (FDA) for the treatment of
ADD and ADHD.
Off-label uses include the treatment of
depression and
anxiety.
Reboxetine, unavailable in the United States and Canada, has been found to be effective at combating depression.
Radafaxine, a potent metabolite of Bupropion, is currently being developed by
GlaxoSmithKline.
Further Information
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